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RESEARCH, PAPERS, AND PEER-REVIEWED EVIDENCE

Holmusk is solving some of the most complex challenges in behavioral health, using AI/ML techniques and our proprietary real-world data. Below is a selection of our conference presentations and peer-reviewed publications.

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The Journal of Clinical Psychiatry

Learning by Doing: Can Our Collective Experiences as Clinicians Improve Mental Health Care?

A. John Rush, MD, and Tony Tramontin, PhD

July 17, 2024

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Peer-reviewed paper
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Addiction

Predictability of buprenorphine-naloxone treatment retention: A multi-site analysis combining electronic health records and machine learning

Fateme Nateghi Haredasht et al.

June 24, 2024

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Peer-reviewed paper
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Duke-Margolis Institute for Health Policy

Real-World Evidence to Support Causal Inference: Methodological Considerations for Non-Interventional Studies

Nora Emmott et al.

June 18, 2024

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Others

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Others
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Duke-Margolis Institute for Health Policy

Regulatory Fit-for-Purpose Considerations for Patient-Generated Health Data

Nora Emmott et al.

May 31, 2024

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Others

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Others
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American Society of Clinical Psychopharmacology

The clinical global impression of severity (CGI-S): Bridging the research-practice gap

Joydeep Sarkar et al.

May 30, 2024

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Schizophrenia International Research Society

Clinical characteristics of patients with cognitive impairment associated with schizophrenia

Theresa Cassidy et al.

April 6, 2024

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Schizophrenia International Research Society

Long-term patient functioning and illness burden associated with cognitive impairment and negative symptoms in schizophrenia

Kira Griffiths et al.

April 5, 2024

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Conference abstract
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Neuropsychiatric Disease and Treatment

Psychometric evaluation and linking of the PHQ-9, QIDS-C, and VQIDS-C in a real-world population with major depressive disorder

Palmer et al.

March 26, 2024

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Peer-reviewed paper

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Peer-reviewed paper
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Natural Language Processing Journal

Enhancing pre-trained contextual embeddings with triplet loss as an effective fine-tuning method for extracting clinical features from electronic health record derived mental health clinical notes

Kulkarni et al.

December 8, 2023

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Peer-reviewed paper
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European College of Neuropsychopharmacology Congress

Treatment trajectory in people with borderline personality disorder from diagnosis to 12 months post-diagnosis

White et al.

October 10, 2023

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Conference abstract
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European College of Neuropsychopharmacology Congress

Treatment trajectory in people with major depressive disorder from diagnosis to 12 months post-diagnosis

St.Rose et al.

October 10, 2023

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Conference abstract
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European College of Neuropsychopharmacology Congress

Examining differences in clinical and demographic characteristics of patients with post-traumatic stress disorder across adults and paediatric subgroups

Abramsky et al.

October 10, 2023

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Conference abstract
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European College of Neuropsychopharmacology Congress

Examining real-world evidence of clinical outcomes, healthcare resource utilisation and treatment patterns of patients with post-traumatic stress disorder

Abramsky et al.

October 10, 2023

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European College of Neuropsychopharmacology Congress

Clinical characteristics of people with borderline personality disorder at 12 months prior to first diagnosis and at diagnosis

White et al.

October 9, 2023

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Conference abstract
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Therapeutic Advances in Psychopharmacology

Comparative effectiveness study of paliperidone palmitate 6-month with a real-world external comparator arm of paliperidone palmitate 1-month or 3-month in patients with schizophrenia

Ibrahim Turkoz et al.

September 29, 2023

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Peer-reviewed paper

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Peer-reviewed paper
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Duke-Margolis Center for Health Policy

Improving Patient Subgroup Representation with Real-World Data

Nora Emmott et al.

September 28, 2023

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Others

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Others
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Schizophrenia Research

Associations of comorbid substance use disorders with clinical outcomes in schizophrenia using electronic health record data

Rashmi Patel et al.

September 11, 2023

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Peer-reviewed paper

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Peer-reviewed paper
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International Conference on Pharmacoepidemiology

Real-world evidence on the burden of known side-effects of typical and atypical antipsychotic medications in patients with schizophrenia

Joshua Wong et al.

August 26, 2023

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American Society of Clinical Psychopharmacology

Elevated anxiety in patients with major depressive disorder

A. John Rush et al.

June 1, 2023

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Schizophrenia International Research Society

Identifying the treatment gap of undiagnosed tardive dyskinesia: an analysis of unstructured electronic health record data

Kira Griffiths et al.

May 14, 2023

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International Professional Society for Health Economics and Outcomes Research

Development of a novel transdiagnostic predictor of psychiatric hospitalization using early trajectories of the Clinical Global Impression Scale

Maxime Taquet et al.

May 10, 2023

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International Professional Society for Health Economics and Outcomes Research

Investigating trends of behavioral healthcare resource utilization burden in children and adolescents with suicidal symptoms in the United States: An analysis of electronic health record data

Sherwin Kuah et al.

May 10, 2023

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International Professional Society for Health Economics and Outcomes Research

A comparison of oral aripiprazole with an ingestible sensor to oral atypical antipsychotic treatment in a real-world setting for the risk of hospitalization in adults with schizophrenia

D. Hadzi Boskovic et al.

May 9, 2023

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European Congress of Psychiatry

A real-world data analysis of Clinical Global Impression-Severity (CGI-S) as a transdiagnostic predictor of psychiatric hospitalization

Emily Palmer et al.

March 28, 2023

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The Lancet Psychiatry

Early trajectory of clinical global impression as a transdiagnostic predictor of psychiatric hospitalisation: a retrospective cohort study

Maxime Taquet et al.

March 23, 2023

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Peer-Reviewed Paper

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Peer-reviewed paper
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Academy of Managed Care Pharmacy

Real-world insights into long-acting injectable antipsychotic agent initiation in the inpatient setting and transition/continuation of care: Impact of LAI characteristics on outcomes among patients with schizophrenia

Stephen Thompson et al.

March 23, 2023

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Academy of Managed Care Pharmacy

Early clinical instability and increased risk of psychiatric hospitalization: real-world evidence from an analysis of electronic health record data

Maxime Taquet et al.

March 22, 2023

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ClinicoEconomics and Outcomes Research

Life engagement improvement following initiation of brexpiprazole treatment in patients with MDD: A naturalistic, retrospective real-world study

Christian Liman et al.

March 18, 2023

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Peer-Reviewed Paper

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Peer-reviewed paper
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Current Medical Research and Opinion

Psychiatric Healthcare Resource Utilization Following Initiation of Aripiprazole Once-Monthly: A Retrospective Real-world Study

Heidi C. Waters et al.

December 17, 2022

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Peer-reviewed paper
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American College of Neuropsychopharmacology

Gender Differences in Adult ADHD Symptoms: Network Analysis of Real-world Data

Kira Griffiths et al.

December 5, 2022

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National Institute of Health Research MindTech

The impact of a caseload management tool (MaST) on community mental healthcare service delivery

Caroline Gadd et al.

November 24, 2022

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Conference abstract
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DGPPN German Association for Psychiatry, Psychotherapy and Psychosomatics

The application of natural language processing to real-world electronic health record data to identify positive and negative symptoms in schizophrenia

Rashmi Patel et al.

November 23, 2022

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DGPPN German Association for Psychiatry, Psychotherapy and Psychosomatics

The impact of COVID-19 on psychiatric illness severity and care delivery: A real-world data study

Emily Palmer et al.

November 23, 2022

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International Professional Society for Health Economics and Outcomes Research: Europe

Predictors Of Hospitalization In Patients With Newly Diagnosed Major Depressive Disorder: A Real-world Evidence Study

Nicole Croteau et al.

November 6, 2022

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International Professional Society for Health Economics and Outcomes Research: Europe

Transdiagnostic Analysis of Mental Disorder Symptoms Associated with Increased Frequency of Psychiatric Hospitalization

Emily Palmer et al.

November 6, 2022

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Conference abstract
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American Academy of Child & Adolescent Psychiatry

The Impact of Executive Functioning Deficit on Illness Severity in Patients with an ADHD Diagnosis: a Real-world Data Study

Emily Palmer et al.

October 17, 2022

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European College of Neuropsychopharmacology

The Association of Comorbid Substance Use Disorders with Time to Treatment Discontinuation in Patients with Schizophrenia

Rashmi Patel et al.

October 15, 2022

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European College of Neuropsychopharmacology

Antipsychotic prescribing trends in schizophrenia between 2011 and 2021: real-world data from a US electronic health record database

Kira Griffiths et al.

October 15, 2022

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Conference abstract
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Academy of Managed Care Pharmacy: Nexus

Antipsychotic Treatment Patterns in Patients with Schizophrenia

Rashmi Patel et al.

October 11, 2022

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Psych Congress

Associations Between Cognitive Symptoms and Poor Clinical Outcomes in Schizophrenia: Real-world Evidence from an Electronic Health Record Study

Kira Griffiths et al.

September 17, 2022

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Conference abstract
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Psych Congress

A Network Analysis of Borderline Personality Disorder Symptoms: A Real-world Data (RWD), Electronic Health Record (EHR) Study

Emily Palmer et al.

September 17, 2022

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European Conference on Mental Health

The Impact of a Caseload Management Tool (MaST) on Community Mental Health Team Care Contacts with Mental Health Service Users

Caroline Gadd et al.

September 14, 2022

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Conference abstract
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Royal College of Nursing

Evaluation of the Impact of the Use of a Caseload Management Tool (MaST) in Mersey Care NHS Foundation Trust

Caroline Gadd et al.

September 6, 2022

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Conference abstract
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Psychiatric Times

Digital Health as an Enabler for Patient-Centric, Outcome-Based Care

Nawal Roy et al.

August 11, 2022

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Peer-Reviewed Paper

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Peer-reviewed paper
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BJ Psych Open

Derivation and Validation of the Management and Supervision Tool (MaST) Risk of Crisis (RoC) Algorithm Using Electronic Health Record (EHR) Data

Rashmi Patel et al.

June 20, 2022

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Conference abstract
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Faculty of Clinical Informatics

A Validation of The Management and Supervision Tool (MaST) to aid NHS mental health teams in identifying patients needs for either psychiatric hospital admission or home treatment

Caroline Gadd

June 16, 2022

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European Congress of Psychiatry

NeuroBlu: A Natural Language Processing (NLP) Electronic Health Record (EHR) Data Analytic Tool to Generate Real-world Evidence in Mental Healthcare

Rashmi Patel et al.

June 4, 2022

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European Congress of Psychiatry

The Management and Supervision Tool (MaST): An Electronic Crisis Risk Prediction Tool to Support Safe and Effective Mental Healthcare

Rashmi Patel et al.

June 4, 2022

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American Society of Clinical Psychopharmacology

Challenges and Opportunities in the Use of Real-world Evidence to Advance Treatment Development in Behavioral Health

Scott Kollins

May 31, 2022

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American Society of Clinical Psychopharmacology

Healthcare Resource Use Decreases Following Initiation of Aripiprazole 400mg Long-acting Injectable: A Real-World Electronic Health Record Database Study

Heidi C. Waters et al.

May 31, 2022

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Conference abstract
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American Society of Clinical Psychopharmacology

Identifying Patients with High Burden of Positive and Negative Schizophrenia Symptoms in Electronic Health Record Data Using Natural Language Processing

Rashmi Patel et al.

May 31, 2022

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American Psychiatric Association

Relationship Between Polypharmacy and Clinical Functioning in Patients With ADHD: A Retrospective Analysis of Real World Data

Matthew Valko et al.

May 21, 2022

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Conference abstract
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American Psychiatric Association

A Transdiagnostic, Natural Language Processing Analysis of Mental Disorder Symptom Burden Using Electronic Health Record Data

Rashmi Patel et al.

May 21, 2022

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Conference abstract
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International Professional Society for Health Economics and Outcomes Research

Illness Severity Associated with Comorbid Substance Use Disorders in Schizophrenia: An Electronic Health Record Study

Rashmi Patel et al.

May 18, 2022

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Conference abstract
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international Professional Society for Health Economics and Outcomes Research

How Effective Is Antidepressant Medication (ADM) Polypharmacy in Difficult to Treat Depression (DTD)? a Neuroblu Electronic Health Record (EHR) Report

Matthew Valko et al.

May 16, 2022

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Conference abstract
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Journal of Alzheimer's Disease

Alzheimer’s Disease: Key Insights from Two Decades of Clinical Trial Failures

C. Kwon Kim et al.

May 3, 2022

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Peer-Reviewed Paper

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Peer-reviewed paper
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BMJ Open

NeuroBlu, an Electronic Health Record (EHR) Trusted Research Environment (TRE) to Support Mental Healthcare Analytics with Real-world Data

Rashmi Patel et al.

April 22, 2022

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Peer-reviewed paper
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Schizophrenia International Research Society

Positive and Negative Symptoms in Schizophrenia: A Natural Language Processing Study of Realworld Electronic Health Record Data

Rashmi Patel et al.

April 6, 2022

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Conference abstract
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Schizophrenia International Research Society

Associations of Comorbid Substance Use Disorders with Healthcare Service Utilization: A Cohort Using Electronic Health Record Data

Rashmi Patel et al.

April 6, 2022

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Conference abstract
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The Journal of Child Psychology and Psychiatry

Editorial: The Gathering Storm: A U.S. Perspective on the Scientific Response to the COVID-19 Child and Adolescent Mental Health Crisis

Scott Kollins

February 14, 2022

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Others

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Others
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PLOS Digital Health

Best Practices in the Real-world Data Life Cycle

Jordan Abdi et al.

January 18, 2022

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Peer-reviewed paper

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Peer-reviewed paper
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The American Professional Society of ADHD and Related Disorders

Treatment Response and Time to Treatment Discontinuation in Young Children with ADHD: An Analysis of Real-World Data from Electronic Medical Records

Scott Kollins et al.

January 15, 2022

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Holmusk Whitepapers

The Need for Real-World Evidence to Close the Behavioral Health Evidence Gap

Holmusk

December 16, 2021

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Others

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Others
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American College of Neuropsychopharmacology

Are Symptoms and Functioning Distinct Depression Treatment Targets in the Real World?

Scott Kollins, PhD et al.

December 8, 2021

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Conference abstract
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INTERNATIONAL SOCIETY FOR PHARMACOECONOMICS AND OUTCOMES RESEARCH ANNUAL EUROPEAN CONGRESS

Impact of Comorbid Cannabis Use Disorders in Schizophrenia: An Electronic Health Record Real World Data Study

Rashmi Patel et al.

November 30, 2021

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Conference abstract
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Psych Congress

Patient life engagement improvements associated with brexpiprazole

Soon Nan Wee et al.

November 1, 2021

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Neuropsychiatric Disease and Treatment

Factors That Affect Patient Attrition in Buprenorphine Treatment for Opioid Use Disorder: A Retrospective Real-World Study Using Electronic Health Records

Sheryl Ker et al.

October 28, 2021

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Peer-reviewed paper
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American Academy of Child & Adolescent Psychiatry (AACAP) 68th Annual Meeting

Relationship Between Polypharmacy and Clinical Functioning in Patients With ADHD: A Retrospective Analysis of Real-World Data

Matthew Valko et al.

October 1, 2021

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Informatics in Medicine Unlocked

A Neural System Dynamics Modeling Platform and its Applications in Randomized Controlled Trial Data Analysis

Nadira Hamid et al.

June 12, 2021

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Peer-reviewed paper
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American Society of Clinical Psychopharmacology Annual Meeting

Buprenorphine Treatment Retention in Individuals with Opioid Use Disorder: Insights from Real-World Dataset

Anisha Balani et al.

June 1, 2021

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American Society of Clinical Psychopharmacology Annual Meeting

NeuroBlu®: A Longitudinal Real-World Evidence Platform for Behavioral Health Research

Qian Chen et al.

June 1, 2021

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American Society of Clinical Psychopharmacology Annual Meeting

Natural Language Processing-Based Quantification of the Mental State of Psychiatric Patients

Sankha S. Mukherjee et al

June 1, 2021

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The Journal of Child Psychology and Psychiatry

Editorial: Is Child Mental Health Research Structurally Racist?

Scott Kollins

January 28, 2021

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Others

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Others
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Journal of Computational Psychiatry

Natural Language Processing-Based Quantification of the Mental State of Psychiatric Patients

Sankha S. Mukherjee et al.

December 31, 2020

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Peer-reviewed paper
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Holmusk

Generalized Modeling Framework for Disease Progression in Chronic & Mental Health

Nawal Roy & Joydeep Sarkar

November 1, 2020

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Others

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Others
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International Journal of Bipolar Disorders

The Effects of Vagus Nerve Stimulation on the Course and Outcomes of Patients with Bipolar Disorder in a Treatment-resistant Depressive Episode: a 5-year Prospective Registry

R Hamish McAllister-Williams et al.

May 2, 2020

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Historic MindLinc publication

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Historic MindLinc publication
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Holmusk

Digital Therapeutics in Asia - The Key to Managing Healthcare Costs

Yau Teng Yan & Nawal Roy

May 12, 2018

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Others

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Others
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Psychiatric Quarterly

Antidepressant Regulatory Warnings, Prescription Patterns, Suicidality and Other Aggressive Behaviors in Major Depressive Disorder and Anxiety Disorders

Saurabh Gupta et al.

August 25, 2015

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Historic MindLinc publication

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Historic MindLinc publication
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Psychiatric Services

Use of Augmentation Agents for Treating Depression: Analysis of a Psychiatric Electronic Medical Record Data Set

Kenneth R. Gersing et al.

August 1, 2014

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Historic MindLinc publication

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Historic MindLinc publication
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Journal of Psychiatric Research

Co-morbid Substance Use Disorders with Other Axis I and II Mental Disorders Among Treatment-seeking Asian Americans, Native Hawaiians/Pacific Islanders, and Mixed-race People

Li-Tzy Wu et al.

September 9, 2013

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Historic MindLinc publication

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Historic MindLinc publication
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Journal of Psychiatric Research

Using Electronic Health Records Data to Assess Comorbidities of Substance Use and Psychiatric Diagnoses and Treatment Settings Among Adults

Li-Tzy Wu et al.

January 19, 2013

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Historic MindLinc publication

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Historic MindLinc publication
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The Primary Care Companion for CNS Disorders

The Effectiveness of Antidepressant Monotherapy in a Naturalistic Outpatient Setting

Tih­-Shih Lee et al.

October 4, 2012

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Historic MindLinc publication

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Historic MindLinc publication
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American Journal of Geriatric Psychiatry

Cognitive Improvement Following Treatment in Late Life Depression: Relationship to Vascular Risk and Age of Onset

Deanna M. Barch et al.

August 1, 2012

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Historic MindLinc publication

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Historic MindLinc publication
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Clinical and Translational Science

Patient Electronic Health Data-driven Approach to Clinical Decision Support

Ketan K Mane et al.

October 1, 2011

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Historic MindLinc publication

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Historic MindLinc publication
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Journal of Biomedical Informatics

VisualDecisionLinc: A Visual Analytics Approach for Comparative Effectiveness-based Clinical Decision Support in Psychiatry

Ketan K. Mane et al.

September 20, 2011

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Historic MindLinc publication

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Historic MindLinc publication
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Journal of Psychiatric Research

Substance Use Disorders and Comorbid Axis I and II Psychiatric Disorders Among Young Psychiatric Patients: Findings from a Large Electronic Health Records Database

Li-Tzy Wu et al.

July 13, 2011

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Historic MindLinc publication

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Historic MindLinc publication
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JAMA Psychiatry

Support for the Vascular Depression Hypothesis in Late-Life Depression: Results of a 2-Site, Prospective, Antidepressant Treatment Trial

Yvette I. Sheline et al.

March 1, 2010

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Historic MindLinc publication

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Historic MindLinc publication
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Psychosomatics

Prevalence of HIV Infection in a General Psychiatric Outpatient Population

John L Beyer et al.

February 1, 2007

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Historic MindLinc publication

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Historic MindLinc publication
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Biological Psychiatry

Cognitive Function in Late Life Depression: Relationships to Depression Severity, Cerebrovascular Risk Factors and Processing Speed

Yvette I. Sheline et al.

July 1, 2006

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Historic MindLinc publication

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Historic MindLinc publication
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Neuropsychopharmacology

Medical Comorbidity in a Bipolar Outpatient Clinical Population

John L Beyer et al.

November 10, 2004

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Historic MindLinc publication

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Historic MindLinc publication